By winning the first Test by an innings, the tourists set a number of records, including the highest declared total of 823-7 since 1938.
A successful chase would easily be their biggest chase to win a Test in Asia, as they have been set 297 to win the second Test.
England finished the third day of the second Test with a 36-2 score on a dusty field in Multan that was used again for the first game and, therefore, its eighth day of play.
“We will continue to hold that belief,” Collingwood stated. “We will find methods to put pressure on them, but we must be realistic and acknowledge that it will be difficult.
It would also be the best by any visiting team in Pakistan and their joint third-highest in an overseas Test if England were to succeed in the chase.
On the third day, England finally dismissed Pakistan for 221 after allowing a 75-run deficit in the first innings.
They lost openers Ben Duckett and Zak Crawley despite being granted 11 overs to bat before the end.