Two-thirds of the parliamentarians in the upper chamber of parliament must vote against the deputy president, who is defending himself before them on Thursday.
Among the eleven counts against him include undermining the government, promoting ethnic divides, and corruption.
The allegations were read out in the house, and the deputy president entered not guilty pleas to each of them as the trial got underway on Wednesday.
His impeachment was approved by a resounding majority of members of the National Assembly last week, paving the way for the Senate trial.
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Only two years after they were elected together on a same ticket, he and President William Ruto have a falling out.
The dispute started in June when a large number of irate Kenyans staged lethal protests in the streets against unpopular tax increases.
The member who had made the motion, Mwengi Mutuse, spoke in the Senate on Wednesday, accusing Gachagua of constitutional violations as he walked the chamber through the motion’s several grounds.
Gachagua’s comments that the government was like a stock firm and that only those who committed “extraordinary” misbehavior would be impeached were among the charges he used to frame the deputy president.