In connection with the attack on the 16-year-old, who has not been identified, the teenagers were taken into custody late on Thursday.
The 16-year-old, who has not been identified, was attacked in Rawnsley Park’s St. Philips neighborhood.
He ran to Stapleton Road, where he was assisted by a car, and then he passed out on West Street.
Police reported that although ambulances were dispatched, the man passed away at the site.
Bristol Commander for Avon and Somerset Police, Supt Mark Runacres, stated: “The team looking into yesterday’s incident is working around the clock to bring those responsible to justice.”
“Two 15-year-old boys were taken into police custody this evening (Thursday) in relation to the investigation, and they will be questioned.”
“We are all thinking about the victim’s family and loved ones at what is surely a very trying moment.
“Specialist family liaison officers have been assigned to the family to provide them with support and keep them updated on the investigation.”