Angiodema can be extremely crippling, impair breathing, and occasionally be fatal. It is estimated that 50,000 people worldwide suffer from this condition.
Individuals receiving a single dosage of Crispr-Cas9 gene therapy did not exhibit many new symptoms.
The therapy offers a great deal of promise as a treatment for further genetic disorders.
“It appears that the one-time medication will offer a lasting solution for the extremely incapacitating symptoms that my patients with hereditary angioedema suffer,” stated lead researcher Dr. Hilary Longhurst, a clinical immunologist at Auckland Hospital.
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Angiodema can affect many different body areas and is characterized by swelling in the soft tissues.
A Suffolk resident named Cleveland Firman, who underwent therapy in the UK, stated: “Trying to live my life has become nearly impossible due to the attacks’ randomness, unpredictability, and potential severity.” I’ve wondered all my life whether my next attack would be serious or not.
“The swellings cause discomfort and are unsightly. I felt ashamed to leave in case there was an assault. I was admitted to the hospital because of swellings in my throat and neck that were making it difficult for me to breathe.
“I have not experienced an attack since the procedure. My physical and mental health have drastically improved.”I have a lot of optimism for the future. I’m volunteering now so I can connect with like-minded others. My world has opened up and my confidence has grown as a result of the independence.”
