Liverpool’s McCann, 34, stepped down from flyweight in February and defeated Diana Belbita to snap a two-fight losing streak.
Brazil’s Brasil, 30, fell to Loma Lookboonmee three months ago but has won one of her three UFC fights.
The main event at Manchester’s Co-op Live Arena features Birmingham’s Leon Edwards defending his welterweight belt against American Belal Muhammad.
The co-main event features Manchester’s interim heavyweight champion Tom Aspinall defending his title against American Curtis Blaydes.
McCann, who has won seven of her twelve UFC fights since debuting in the promotion in 2018, joins fellow Liverpudlian Paddy Pimblett on a card.
