The 36-year-old suffered the injury during his third-round Miami Open loss.
Murray will miss the April clay-court Monte Carlo Masters and Open in Munich, according to a spokeswoman, after consulting with medical professionals.
In the past, the three-time Grand Slam winner has stated that he did not intend to “play much past this summer.”.
After continuing to play and losing 5-7, 7-5, 7-6 (7-5) against Machac, Murray revealed the severity of his injuries on Monday.
The Scottish man said that he had ruptured his anterior talofibular ligament completely and his calcaneofibular ligament almost completely.
According to a statement from Murray’s management team, it is yet unclear how long Andy will be sidelined. He is currently discussing his options with his medical staff.
Andy has expressed his disappointment at this news and his wish to return to court as soon as possible.