After the incident late in the third set of his thrilling 5-7 7-5 7-6 (7-5) loss to Tomas Machac on Sunday, the 36-year-old Briton requested medical attention.
He attested to having sustained a near-full thickness rupture of the calcaneofibular ligament and a complete rupture of the anterior talofibular ligament.
Murray will now consult with an expert to ascertain the course of action.
Boulter of Britain falls to Azarenka in the Miami fourth round.
Alcaraz and Zverev get it to the Miami Final 16.
Following hip resurfacing surgery in 2019, the three-time major winner commented, “[It] goes without saying this is a tough one to take.”
However, he stated, “I’ll be back with one hip and no ankle ligaments when the time is right.”
Murray, who turns 37 in May, stated earlier this year that he only intended to “play much past this summer” but that he intended to participate in one more Olympic Games before calling it quits.
He said he would like to play one last time in the French Open, which gets underway on May 26 at Roland Garros.