A blast is purportedly near a fuel station in the southeast city of Feodosiya, according to a image that has been uploaded online.
According to Russian officials, 38 drones were shot down. The Kerch bridge, which links Russia and Crimea, was briefly shut down.
The strike occurs as Ukraine is pressuring friends to increase armament supplies.
Recently, as Kyiv battles to maintain its soldiers with weapons developed in the West, Russian troops have gained ground in Ukraine. Last month, Moscow seized control of Avdiivka, a crucial town in the east.
But this has come at a heavy price, according to British military intelligence.