In their second Group B match on Thursday, Spain and Italy will square off once more as they both aim to further establish their stellar records in the tournament.
Protecting the winners Spain has won the competition three times, in 1964, 2008, and 2012. Italy has won the competition twice.
From Xavi to Jorginho, and from Andreas Iniesta to Andrea Pirlo, these teams have produced some of the greatest players this generation has ever seen.
BBC Sport revisits six of these titans of 21st-century football, taking fans on a walk down memory lane.
Spain defeats Italy 2-1 in the Nations League semifinal (June 2023)
In their most recent match, Real Madrid supersub Joselu’s late goal was necessary for Luis de la Fuente’s team to get to the Nations League final, where they ultimately defeated Croatia.
Yeremy Pino scored the first goal early on, and Ciro Immobile answered with a penalty kick.
Joselu’s lucky goal three minutes from the end gave Spain the victory over Italy.
With two goals in the first half from Ferran Torres, Spain advanced to the Nations League final in 2021 at the San Siro in a commanding performance.
At the end of the first half, Italian legend Leonardo Bonucci was sent off, and in the second half, Lorenzo Pellegrini cut the deficit in half.