Due to a calf injury, Jones was unable to play in the crushing 37-5 loss to Australia, and Tuipulotu remained in the UK attempting to resolve her visa-related concerns.
On Sunday, the tight-head prop reunited with the team in Cape Town.
Jones’s return to the center of the field causes a change in the backline, as Jasmine Joyce moves to full-back and Carys Cox to the wing.
The pack stays the same, with Molly Reardon, Alaw Pyrs, and Maisie Davies, three under-20 players, sitting on the bench.
Italy has changed a few things after their 19-0 loss to Scotland, the current WXV2 champions.
Giordana Duca is named at lock, and Silvia Turani and Vittoria Vecchini reappear in the front row.
A new-look back row is formed by Sara Tounesi, Francesca Sgorbini, and Elisa Giordano, while Michela Sillari, a veteran player, returns from injury to play in the middle.
The backline is still the same.
After heartbreaking losses in the first round, both teams will be trying to turn things around.
Wales has defeated the Azzurre in their last two encounters, winning their lone game at the Women’s Six Nations this year in a close match at the Principality Stadium.
