Since co-captain Sam Monaghan is not listed in the matchday roster for the game, Enya Breen is substituted to the bench.
Head coach Scott Bemand drafts in Meabh Deely as a replacement.
Ireland hopes to improve on last weekend’s thrilling 36-5 victory against Wales in Cork.
Cokayne is suspended for England’s match against Ireland.
After losses to France and Italy, the Irish’s first victory of the campaign lifted them to third place in the rankings, but Bemand is aware that a difficult test against the reigning champions and table-toppers is ahead.
We have another opportunity to play as a group, in front of a large audience at an amazing venue. In both training and games, we are gaining some traction. We want to put ourselves to the greatest among them, and this is the test we want,” Bemand remarked.