Dramatic images showed the devastation left in Greenfield, with authorities confirming deaths and at least a dozen injuries but unable to provide specific figures.
Multiple tornadoes ripped through the Midwest, causing devastation.
An suspected tornado in southwest Iowa brought down at least three 250-foot-high wind turbines.
One turbine was engulfed in flames, with black smoke pouring from the twisted frame.
Officials stated the majority of Greenfield, which had a population of around 2,000 people, had been destroyed, and rescue efforts were still underway to discover survivors.
Sgt Alex Dinkla, an Iowa State Patrol official, said: “This tornado has done it.