Mr Ciccone, who was a craftsman, artist and creator, kicked the bucket on Friday in Michigan subsequent to being determined to have malignant growth.
In a post on Instagram, Madonna, 66, said Ciccone was in “such a lot of torment towards the end”.
She said: “He was the nearest human to me for such a long time, making sense of our bond is hard.
“Yet, it outgrew a comprehension that we were unique and society planned to give us trouble for not following the norm.
“We took each other’s hands and we moved through the franticness of our experience growing up, as a matter of fact dance was a sort of superglue that kept us intact.
“Finding dance in our little Midwestern town saved me and afterward my sibling went along, and it saved him as well. My expressive dance instructor, likewise named Christopher, made a place of refuge for my sibling to be gay, a word that was not verbally expressed or even murmured where we resided.
“At the point when I at last got the fortitude to go to New York to turn into an artist, my sibling followed, and again we took each other’s hands, and we moved through the franticness of New York City.