Following Lleucu George’s knee injury sustained during last week’s loss to Italy, Kayleigh Powell enters the game at fly-half.
Sisilia Tuipulotu takes the lead from the outset, and Abbie Fleming is the chosen lock over Georgia Evans.
Wales sit at the bottom of the standings with just one bonus point after losing both of their first rounds.
After the Rugby World Cup the following year, in 2026, they will play again in the competition, and a victory over Japan will keep them in WXV3.
In the event that Wales earns a try bonus point and Italy suffers a significant loss to South Africa without claiming a bonus, they may afford to draw.
But they will be looking to bow out with a win for what has been a disappointing campaign.
Japan are also looking for a first tournament victory, but sit above Wales after picking up three bonus points in their games against South Africa and Scotland.
“We have focused on ourselves this week and what we do well and what we have to put right after the Italy game,” said Wales head coach Ioan Cunningham.
“We had an honest review and the message to the players has centred around composure and calmness and finishing the opportunities we are creating.
“Test match rugby is about turning pressure into points, and we have created enough chances in both our previous Test matches, but we need to be more clinical when we get in the red zone against Japan.